The DNA secondary structures at telomeres and genome instability
نویسندگان
چکیده
منابع مشابه
DNA secondary structures and epigenetic determinants of cancer genome evolution
950 VOLUME 18 NUMBER 8 AUGUST 2011 NAture StructurAL & moLecuLAr bIoLogY Loss of genomic integrity is a common hallmark of cancer genomes1. Recent technological advances have led to several large-scale cancer genome profiling studies2–5 that have identified genome-wide patterns of alterations in many cancer samples. Notably, DNA breakpoints in cancer genomes, and also in the genomes of apparent...
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DNA methylation is a type of epigenetic changes that directly affects DNA. In mammals, DNA methylation is essential for fetal development and stem cell differentiation and this phenomenon essentially occurs within the CpG islands. In this study, two methods were used to study the DNA methylation profile of cow genome. In the first method, the DNA methylation profile of the differentially expres...
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In view of the differences of the X-ray diffraction patterns for DNA fibers at 66 and 92 per cent relative humidities, it is proposed that the secondary structure of DNA consists of two partially intercalated double helices at 92 per cent. Possible biological implications are discussed.
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DNA secondary structures containing regions of single-stranded DNA have now been identified in the genomic DNA of a number of prokaryotic and eukaryotic species, including humans. Many of these secondary structures are associated with regions of DNA involved in regulation of transcription: promoters or upstream elements. The secondary structures involved appear likely to be hairpin or cruciform...
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ژورنال
عنوان ژورنال: Cell & Bioscience
سال: 2020
ISSN: 2045-3701
DOI: 10.1186/s13578-020-00409-z